Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19
Abstract The most common cause of death due to COVID-19 remains respiratory failure.Yet, our understanding of the precise cellular and molecular changes underlying lung alveolar damage is limited.Here, we integrate single cell transcriptomic data of COVID-19 and donor lung tissue with spatial transcriptomic data stratifying histopathological chervo