INTEGRATED HISTOPATHOLOGY, SPATIAL AND SINGLE CELL TRANSCRIPTOMICS RESOLVE CELLULAR DRIVERS OF EARLY AND LATE ALVEOLAR DAMAGE IN COVID-19

Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19

Abstract The most common cause of death due to COVID-19 remains respiratory failure.Yet, our understanding of the precise cellular and molecular changes underlying lung alveolar damage is limited.Here, we integrate single cell transcriptomic data of COVID-19 and donor lung tissue with spatial transcriptomic data stratifying histopathological chervo

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The Protective Effects and Immunological Responses Induced by a Carboxymethyl Cellulose Microcapsule-Coated Inactivated Vaccine Against Largemouth Bass Ranavirus (LMBRaV) in Largemouth Bass (Micropterus salmoides)

Background: Epizootics of largemouth bass ranavirus (LMBRaV) in largemouth bass (Micropterus salmoides) populations are associated with elevated mortality and significant financial losses.Given the lack of effective and safe medication to treat this disease, oral vaccination, which directly targets the intestinal mucosal immune system, is crucial f

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Nonlinear dynamics as a ground-state solution on quantum computers

For the solution of time-dependent nonlinear differential equations, we present variational quantum algorithms (VQAs) that encode both space and time in qubit registers.The spacetime encoding enables viqua-f4 us to obtain the entire time evolution from a single ground-state computation.We describe a general procedure to construct efficient quantum

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